Convegno monotematico SIF su “Aging Brain: in Search of Better Neurotherapeutics”
Rende (CS), 4-5 Maggio 2017, Università della Calabria

The adaptive response to endogenous and external stimuli underlines the neuroplasticity of the brain, i.e.
the complex structural and functional reorganization, cellular and molecular changes, neurogenesis and the cognitive plasticity for better functioning.
Physiological aging stems from the correct execution of such adaptation throughout the lifespan in response to genetic and environmental factors. Hampered neuroplasticity may occur under stressful conditions (including anxiety, depression etc.) and may predispose to neuroprogression toward pathological aging of the brain. Thus, unsuccessful aging process undermines fundamental cellular and molecular mechanisms and brain homeostasis and it is associated with reduced cognitive abilities and enhanced risk to develop dementia and/or neurodegenerative diseases.
Several mechanisms contribute to the latter process and some of these have been recently investigated in depth. Innate and adaptive immunity contribute a great deal to set the histopathological conditions that alter tissue structure and function in aged brain. For instance, pro-inflammatory cytokines and dysfunctional microglia underlie neuroinflammation that causes enhanced blood brain barrier permeability and synaptic simplification. This may occur via mechanisms implicating abnormal excitatory neurotransmission and oxidative and nitrosative stress leading to defective energy metabolism.
Attempt to repair brain damage may be hindered during aging by defective or, even worse, aberrant neurogenesis that may amplify the damage in specific neuronal circuitry via abnormal neuronal cell demise (mainly via apoptosis) or building up anomalous circuits.
Altogether, the above mechanisms are implicated in the onset and progression of age-related neurodegenerative diseases, including  Alzheimer's disease, Parkinson's disease and glaucoma, among others. Thus, the monothematic meeting will be the occasion for young scientists (PhD, Post-Docs etc) to contribute to the success of the meeting with their original research data and to discuss them with scientists of established and worldwide recognized reputation.
 
Maggiori informazioni sono disponibili all’indirizzo:
http://sifmonothematic.wixsite.com/aging-brain-meeting/programme
 
Ultimo aggiornamento: 18.04.2017
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